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HIV

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A good friend of mine works as a doctor in the area of sexual health in the UK. He was kind enough to answer some questions on misconceptions and thoughts about HIV for me.

Clinics are now saying 6 weeks is the length of time after infection that a positive result will show up. Can it take longer?
The traditional ‘window period’ for testing after a specific risk is 12 weeks. However a large number of people who contract HIV have developed antibodies by 6-10 weeks. This has been known for ages. The test that we are discussing is the antibody test,however a viral load test can be positive within a week of the virus infecting someone.
The advice is the same as it always has been
1. HIV test but wait 12 weeks after the risk
2. Occasionally if someone is very anxious can do the HIV antibody test after 6-10 weeks as long as they know to come back at 12 weeks for a repeat test if the first test is negative
3. If someone is having a seroconversion illness we do a Viral load test which is different to the hiv antibody test and not done routinely.

I’ve been told that you will know when you are sero-converting by one person and by another that he didn’t have any idea. Does it affect different people differently?
Studies suggest seroconversion illness occurs in approx 20-30% of patients but the symptoms are very non specific and easily mistaken for a flu/sore throat/diarrhoea ie very common symptoms…which is the problem ,at their most infectious ,most people dont recognise or know they have HIV.

What is your opinion on the theory that there are people who are “immune” to HIV? I do occasionally see people who are having huge risk or long tem partners of known hiv infected partners who never got the infection themselves.


People are living longer and healthier without medication these days. Why do you think that is?
Hmmmmmm not sure we can make a general statement like that….people in Africa may not agree! Patients may be getting tested earlier and so,appear to live longer post diagnosis. In the early days of the epidemic,people were diagnosing in very late stage (AIDS) disease and die shortly after.

How many different strains of HIV would you estimate there might be out there now?
Apart from HIV 1 and HIV 2 , HIV 1 is subclassified into subtypes or clades,the list of wich is growing as different clades recombine and produce what we call recombinants. At the moment approx clades A-G exist plus an endless list of recombinant clades wich have not been classified as yet.

People still think it’s nearly impossible to catch HIV being the “top”. Do you have any statistics on infection rates for the varying sexual roles?
Check the following resource from http://www.bashh.org/guidelines.asp and click the second link under HIV to download a pdf.

go to table 2

Table 2 The risk of HIV transmission following an exposure from a
known HIV-positive individual
Type of exposure
Estimated risk of HIV
transmission per exposure (%)
Blood transfusion (one unit) 90–100
Receptive anal intercourse 0.1–3.0
Receptive vaginal intercourse 0.1–0.27
Insertive vaginal intercourse 0.03–0.09
Insertive anal intercourse 0.06
Receptive oral sex (fellatio) 0–0.04
Needle–stick injury 0.3 (95 CI 0.2–0.5)
Sharing injecting equipment 0.67
Mucous membrane exposure 0.09 (95 CI 0.006–0.5)

Is there any data on the percentage of the gay population currently living with HIV? Seroprevalence in london suggests 15-20% of all gay men london are positive. Not too sure in sydney…check the ASHM website

台長: CCR5
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daniel
hi!
I saw your blog accidently. You seems stop to write blog for a while and live again. Ha...
You raised a lot of difficult questions. I know the winddow period you mentioned. But I have no idea about seroconversion. Never heard people or blog talking about that. Regarding somebody free from infected, I think that either a jok, or the long term partner they got well protection. I am not sure where you live right this moment. Are you stay in London? or Taiwan? There is a website in Taiwan you can check, if you can read Chinese, Lourdes Association (http://lourdes.org.tw/). I think that is a most updated reference for HIV/AIDS in Taiwan. However, some issues that may still need consult profession. Best regards
2008-04-16 07:49:40
CCR5
黑死病增加了歐洲人對HIV的免疫力?
HIV主要是經由和巨噬細胞、CD4+ T細胞膜上的CD4及CCR5受體結合而進入人體,入侵細胞後再脫殼釋出遺傳物質並摧毀免疫系統。在以往的研究中已證實,阻斷細胞上的CCR5受體可以影響病毒進入宿主細胞;若是人體的CCR5受體本身有突變,也會使其不易受到HIV感染。有研究指出,CCR5若突變失去32個鹼基對(CCR5-delta32),將會形成較小之蛋白質而無法於免疫細胞的表面正常表現,因此可以避免HIV的感染。正常人體中每個基因都具有2個副本,CCR5也不例外。若CCR5的基因中只有一個CCR5-delta32變異(heterozygous),只能部分的抵抗HIV-1的感染,如果2個CCR5-delta32都產生變異,便可以對HIV-1產生免疫。
2008-04-20 23:28:22
daniel
hi!你有持續follow這個發現嗎?只是有點不解,如果CCR5-delta32變異有助對抗HIV-1,那麼,人類的基因群不是可以透過物競天擇的原理,把有扺抗力的好基因遺傳下來,最後,HIV-1就再也沒轍了不是嗎,可是,為何此情形沒出現?CCR5-delta32基因變異本身會不會有其他問題,如果沒有,只要能想法子把CCR5-delta32基因弄成變異,不就有解了?不過,以目前的醫療科技,有辦法把基因弄成突變的基因嗎?這對已感染的人會有助益嗎?
2008-04-24 20:17:04
daniel
夭壽哦!
這篇英文也太大篇了吧!
2008-04-25 07:08:22
daniel
至少
知道有人這麼努力在開發aids疫苗
讓人很感動
thanks a lot
2008-04-25 07:33:11
是 (若未登入"個人新聞台帳號"則看不到回覆唷!)
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