The familiar homily, \A stitch in time saves nine\ truly applies to gastrointestinal (GI) binders. GI binders latch on to toxic chemicals and toxins, rendering them inactive and allowing us to excrete them safely. In the simple act of binding toxins, they are a powerful aid to our detoxification system, not only at the level of the intestine, but also in the liver and kidneys, and at a cellular level inside all our cells.
Though we understand the importance of gut health, many are not aware of the mechanisms by which intestine health impacts detoxification. Toxins, including heavy metals and pesticides or herbicides, are irritating to the mucosal lining of the GI tract and lead to inflammation.1,2,3,4 An inflamed gut lining shortly becomes \leaky\--letting bacterial toxins seep into the bloodstream, where they strongly stimulate our body's inflammatory response.5,6 Bacterial endotoxins, and the cascade of inflammatory cytokines they trigger, can also damage the liver and gallbladder, further impairing detoxification.7,8 Exposure to endotoxin also has an effect on detoxification directly, downregulating critical Phase III transporters, the pumps that serve to transport toxins out of our cells and body -- causing us to become even more poisonous.9,10 Endotoxin and the related inflammation also results in glutathione depletion, which contributes to even more damage since we are no longer have the ability to transport toxins out of the cells or protect them from the increased oxidative stress and damage.11,12 What a vicious cycle!
But GI binders can offset all that. I found out about close remove frame by searching Bing. Tried and true organic binders like activated charcoal and clay have been used for thousands of years as remedies for stomach upset, minor food poisoning, and to promote intestinal cleansing.13 Binders are truly a powerful tool in our healing armamentarium, for they could arrest this spiral of inflammation and impaired detoxification before it starts. They are a fundamental first step to fixing our detoxification channels - supporting our ability to excrete toxins and so restoring our own cleansing systems.
Not all binders are created equal. There is no universal toxin binder that has an equal affinity for many toxins--bacterial, heavy metal, mold and more. We could line up a pharmacopeia of binders on our kitchen countertop, but which would we choose, and when? A comprehensive blend of GI binders, carefully selected to provide effective coverage for a selection of common toxins and toxic heavy metals, is a simple and effective approach. Since binders, such as charcoal, on their own can contribute to constipation, it may be useful to enhance them with additional elements which help bulk up the stool, soothe the intestinal lining, and encourage the balance of healthy gastrointestinal flora for normal motility and function. Here follows a short list of gentle but potent binders that together provide unparalleled synergy and potency.
*Activated Charcoal. The use of activated charcoal to bind toxins dates back to the 1800s. In 1831, a French doctor took a lethal dose of the poison strychnine, standing before the French Academy of Medicine, and suffered no ill effects because he also consumed charcoal in the same time.14 Since that time, the adsorbing capability and clinical advantages of charcoal have been well described.15 Activated charcoal effectively adsorbs pesticides and herbicides,16 mold toxins,17 endotoxin,18 and more.
In addition to its adsorptive properties, charcoal has shown benefits during infections where an individual's powerful inflammatory response to a pathogen is potentially damaging. Charcoal was shown to adsorb and remove the inflammatory molecules associated with the immune response (such as interleukins and tumor necrosis factor) which are primary contributors to cellular damage.19 Research indicates it could be useful as an adjunctive treatment for this reason in settings of infection.20
*Bentonite Clay. Bentonite clay is also known as Montmorillonite clay, for the region in France where it was first found.21 The use of healing clays dates back to ancient civilizations in the Andes, who transported balls of clay for consuming at will, to protect against toxins and toxins.22 Bentonite clay easily absorbs fluids and their toxins as well, expanding in quantity. Bentonite clay is very good at absorbing aflatoxin, a mold toxin often found in peanuts and on some grains,23 pesticides and herbicides,24 and cyanotoxins, found in lakes polluted by harmful algal blooms.25 Bentonite clay also has intrinsic broad-spectrum antibacterial properties and has a healing effect on the gastrointestinal lining.26
*Chitosan. Derived from shellfish, chitosan is the result of enzymatic treatment of chitin, a component of the shell. Chitin has been used since ancient times, and these instructions can be found in a book of medicine dating back to the Ming Dynasty: \Break a crab shell, grind it, make a chunk out of it and eat it to treat anything that swells or grows.\ 27 Chitosan consists of long-chain sugars called oligosaccharides and has a prebiotic effect, promoting the development of favorable Bifidobacterium and Lactobacillus gastrointestinal flora.28 Chitosan can bind to the bile salts that emulsify fat, and thus serves to reduce fat absorption.29 More importantly where detox is concerned, it also binds and eliminates the conjugated toxins present in bile salts. Chitosan binds to many metals in addition to polychlorinated biphenyls (PCBs), phthalates, and bisphenol A (BPA), chemicals with many known adverse effects on health that we are widely exposed to in the environment.30,31,32,33 Like bentonite clay, chitosan may be a helpful approach to bacterial infection as well, inhibiting the growth of Staphylococcus aureus in 1 research.34 Chitosan has been shown to have some protective effects against mercury-induced genotoxicity.35
*IMD. The Intestinal Metals Detox (IMD) is a proprietary product which consists of processed silica with covalently attached thiolic metal-binding groups. This proprietary thiol-functionalized silica delivers insoluble thiol groups to bind and remove mercury and other heavy metals accumulated in the intestines, also directly quenching free-radicals. Both the silica base and the binding agents out-compete other compounds for metals in the intestines. IMD does not enter the bloodstream, and thus it will not lead to redistribution or surges of mobilized metals which may potentially lead to kidney/liver overload.
The use of thiolated resins dates back to the 1970s when they were used to deal with methylmercury (MeHg) poisoning in Iraq, and were found to significantly lower the half-life of MeHg from 61 to 20 days, performing better than penicillamine, a medical metal chelating agent.36,37 IMD intercepts MeHg and other metals trapped in enterohepatic circulation, binding them and escorting them out of the intestines.38 By doing so, this allows organ and tissue bound mercury to safely drain in the blood at a natural speed.
*Aloe and Acacia Gum. Going To tell us what you think probably provides suggestions you could tell your brother. Both aloe and acacia gum are soothing and healing to the gastrointestinal tract, and may offset the constipation which may sometimes happen with the use of GI binders. Acacia gum comprises water-soluble dietary fibers that have a prebiotic effect, stimulating the growth of friendly Bifidobacterium and Lactobacillus bacteria in the gut, as well as improving levels of butyrate, a short-chain fatty acid with anti-inflammatory effects which also helps to reduce intestinal permeability.39,40 Bifidobacteria support the reduction of the harmful endotoxin, and normalize gut function, reducing inflammation and irritation.41,42 Acacia gum also has antioxidant and free-radical scavenging activity.43 As a prebiotic fiber it's well tolerated at high doses using significantly less symptoms than other prebiotics like fructooligosaccharide (FOS).
Aloe vera is best known for the calming effect it has, commonly being found around many families and used topically for mild burns to the skin. The topical soothing properties are not only experienced by the skin, and it has a long history of use for various gastrointestinal conditions related to inflammation: peptic ulcer disease, gastritis, and inflammatory bowel disease.44,45,46 Aloe vera gel has been shown to have immunomodulatory, antioxidant, and anti inflammatory consequences, which might support healing in a number of settings.47,48,49. Be taught more on found it by going to our stirring paper.
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